Mood matters. A bright mood can make your day. Serene Science® Optimistic® can help keep your mood in optimal shape. Healthy production of the mood-regulating neurotransmitter serotonin is supported by the key ingredients l-tryptophan, 5-HTP, coenzyme B-6, folic acid and folinic acid. Optimistic features the clinically studied ingredients vitamin D, rhodiola, and St. John’s wort, which have all been shown to support a healthy mood. It helps you have a positive outlook so you can have a productive day.